人口腔角质细胞HOK

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人口腔角质细胞

英文名：Human Oral Keratinocytes
货号：2610
价格：￥14616.00

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人口腔角质细胞：

口腔黏膜角化细胞是口腔疾病主要屏障，保护局部细胞免受微生物和化学物质造成的伤害。它们通过不断产生或受刺激后产生的细胞因子，刺激参与促发炎症反应，这意味着它们可能通过炎症过程潜在地参与口腔感染的调控，该过程需要不同的白细胞介素参与，如IL-1?和IL-18。口腔黏膜角化细胞表达多种不同的细胞标志物，该表达受到目标基因转录过程中钙素诱导变化的影响。口腔黏膜角化细胞与特征明显的皮肤角质细胞在结构和功能上有很大的相似性，并且为研究角质细胞的生物学特性、无限增殖过程、恶性转化提供了良好的模型。

人口腔黏膜角化细胞(HOK)提取于人口腔黏膜组织，原代冻存。每管含有细胞数>5×105cells/ml，此细胞通过Cytokeratine-8, -18 and -19免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。

推荐培养基: 口腔角质细胞培养基(OKM, Cat. No. 2611)

产品使用说明：仅供科研研究使用

货号	2610
产地	美国
缩写	HOK
规格	5 x 10^5 cells/vial
用途	科研
运输	干冰
保存	液氮

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2.) Ho, M.H., Huang, L., Goodwin, J.S., Dong, X., Chen, C.H. & Xie, H. (2016) Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis PLoS One.11

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7.) Li, J., Zhou, J., Zhang, D., Song, Y., She, J. & Bai, C. (2015) Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury J Cell Mol Med. 19

8.) Lee, C.H., Pan, K.L., Tang, Y.C., Tsai, M.H., Cheng, A.J., Shen, M.Y., Cheng, Y.M., Huang, T.T. & Lin, P. (2015) LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation Oncotarget. 6

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11.) Ji W, Lee C, Chen JY, Cheng Y, Yang S, Chen J, Chen H. (2013) "Areca Nut Extract Induces Pyknotic Necrosis in Serum-Starved Oral Cells via Increasing Reactive Oxygen Species and Inhibiting GSK3: An Implication for Cytopathic Effects in Betel Quid Chewers." PLoS One. 8: e63295.

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15.) Kim JS, Yu SK, Lee MH, Park MG, Park E, Kim SG, Lee SY, Kim CS, Kim HJ, Chun HS, Chun SW, Kim DK. (2013) 'MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells.'

16.) Kim JS, Yu SK, Lee MH, Park MG, Park E, Kim SG, Lee SY, Kim CS, Kim HJ, Chun HS, Chun SW, Kim DK. (2013) "MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells." Mol cells. 35: 17-24.

17.) Russo N, Wang X, Liu M, Banerjee R, Goto M, Scanlon C, Metwally t, Inglehart RC, Tsodikov A, Duffy S, Tubergen EV, Bradford C, Carey T, Wolf G, Chinnaiyan AM, D

18.) Kumar B, Yadav A, Lang JC, Cipolla MJ, Schmitt AC, Arradaza N, Teknos TN, Kumar P. (2012) 'YM155 reverses cisplatin resistance in head and neck cancer by decreasing cytoplasmic survivin levels.'

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21.) Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X. (2010) "Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma." Int J Cancer. 127: 505-12.

22.) Mitchell C, Joyce AR, Piper JT, McKallip RJ, Fariss MW. (2010) "Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death." Toxicol Lett. 195: 23-30.

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27.) M?ller-Richter UD, Dowejko A, Zhou W, Reichert TE, Driemel O. (2008) "Different expression of MAGE-A-antigens in foetal and adult keratinocyte cell lines." Oral Oncol. 44: 628-33.

28.) Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA. (2006) "Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides." J Exp Med. 203: 2271-9.

Question1:
Is HOK (human oral keratinocytes) a primary or immortalized cell line?
Answers:
Posted by Karishma Shah on Wednesday, March 9, 2016
Dear customer,
All our cells are normal, primary cells.

Question2:
I use poly-L-lysine to coat my plate to culture HOK(Human Oral Keratinocytes) cells. I also found out that we have poly-D-lysine. Can I use poly-D-lysine to coat my plate and culture HOK or other primary cells?

Answers:

Posted by Karishma Shah on Thursday, September 3, 2015
Hi Mary,
Thanks for asking! Although we have not tested it, poly-D-lysine should work for these cells.

2611	口腔角质细胞培养基	500ML	￥2176.00	放入购物车》
0103	胰酶/EDTA消化液	100ml	￥384.00	放入购物车》
0113	胰酶中和液	100ml	￥384.00	放入购物车》
0143	无血清细胞冻存液	50ml	￥912.00	放入购物车》
0203	台盼蓝	50ml	￥208.00	放入购物车》
0303	磷酸盐缓冲液	500ml	￥288.00	放入购物车》
0403	多聚赖氨酸	1 mg/ml	￥288.00	放入购物车》
0963	角质细胞转染试剂盒	250 Transfections	￥4464.00	放入购物车》