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人BMP-2酶联免疫试剂盒

英文名: Human BMP-2 ELISA Kit
货号:EK0311
价格:¥7020.00
浏览量:2605次
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  • 产品说明
  • 产品规格
  • 参考文献
  • 常见问题

人BMP-2酶联免疫试剂盒描述:


       Bone morphogenetic protein-2 (BMP-2, BMP 2A) belongs to the transforming growth factor beta (TGF-β) superfamily. It is thought to be involved in cartilage and bone formation during embryogenesis, but may have additional functions in morphogenesis as implied by its expression in various organs and embryonic tissues of mice.1 BMP-2 has been identified as a candidate mediator of retinoid activity. BMP-2 protein induces medulloblastoma cell apoptosis, whereas the BMP-2 antagonist noggin blocks both retinoid and BMP-2-induced apoptosis. BMP-2 also induces p38 mitogen-activated protein kinase (MAPK), which is necessary for BMP-2 and retinoid-induced apoptosis.2 Bone morphogenic proteins (BMPs) are known to promote osteogenesis, and clinical trials are currently underway to evaluate the ability of certain BMPs to promote fracture-healing and spinal fusion.3 The standard product used in this kit is recombinant human BMP-2, constituting a dimer by two chains of 114 amino acids with the molecular mass of 26KDa.


       ScienCell's human BMP-2 ELISA Kit is based on standard sandwich enzyme-linked immune-sorbent assay technology. Human BMP-2 specific-specific monoclonal antibodies are precoated onto 8 x 12 divisible strips. The human specific detection monoclonal antibodies are biotinylated. The test samples and biotinylated detection antibodies are subsequently added to the wells and then washed with PBS or TBS buffer. Avidin-Biotin-Peroxidase Complex is added, and unbound conjugates are washed away with PBS or TBS buffer. HRP substrate TMB is used to visualize HRP enzymatic reaction. TMB is catalyzed by HRP to produce a blue color product that changes into yellow after adding acidic stop solution. The intensity of yellow is proportional to the amount of human BMP-2 that is captured in the strips.


产品使用说明:仅供科研研究使用。

货号

EK0311

产地

美国

缩写

hBMP-2-ELISA

规格

96 tests

用途

科研

保存

频繁使用储存在4°C,很少使用储存在-20°C.

运输

胶冰

参考文献

1. GopalRao, V. V. N.; Loffler, C.; Wozney, J. M.; Hansmann, I.The gene for bone morphogenetic protein 2A (BMP2A) is localized to human chromosome 20p12 by radioactive and nonradioactive in situ hybridization.Hum. Genet. 90: 299-302, 1992.
2. Hallahan, A. R.; Pritchard, J. I.; Chandraratna, R. A. S.; Ellenbogen, R. G.; Geyer, J. R.; Overland, R. P.; Strand, A. D.; Tapscott, S. J.; Olson, J. M. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nature Med. 9: 1033-1038, 2003.
3. Cheng, H.; Jiang, W.; Phillips, F. M.; Haydon, R. C.; Peng, Y.; Zhou, L.; Luu, H. H.; An, N.; Breyer, B.; Vanichakarn, P.; Szatkowski, J. P.; Park, J. Y.; He, T.-C. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J. Bone Joint Surg. 85-A: 1544-1552, 2003.

       1. GopalRao, V. V. N.; Loffler, C.; Wozney, J. M.; Hansmann, I.The gene for bone morphogenetic protein 2A (BMP2A) is localized to human chromosome 20p12 by radioactive and nonradioactive in situ hybridization.Hum. Genet. 90: 299-302, 1992.


       2. Hallahan, A. R.; Pritchard, J. I.; Chandraratna, R. A. S.; Ellenbogen, R. G.; Geyer, J. R.; Overland, R. P.; Strand, A. D.; Tapscott, S. J.; Olson, J. M. BMP-2 mediates retinoid-induced apoptosis in medulloblastoma cells through a paracrine effect. Nature Med. 9: 1033-1038, 2003.


       3. Cheng, H.; Jiang, W.; Phillips, F. M.; Haydon, R. C.; Peng, Y.; Zhou, L.; Luu, H. H.; An, N.; Breyer, B.; Vanichakarn, P.; Szatkowski, J. P.; Park, J. Y.; He, T.-C. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J. Bone Joint Surg. 85-A: 1544-1552, 2003.
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